The role of streptococcus mutans in human caries request pdf. The isolation of this particular bacteria has shown that the main product of its anaerobic fermentation is lactic acid. In particular, the evidence that implicates the mutans streptococci ms 81, 209 and the lactobacilli lb as being responsible for the majority of human dental decay will be. This prompted the hypothesis that cytokines elicited by antigens from streptococcus mutans, which frequently dominates shallow lesions, could play a major role in eliciting the initial tcell response in the pulp. Role of streptococcus mutans in human dental decay. Streptococcus mutans, caries and simulation models ncbi. The extent of colonization of mutans streptococci and also, to some degree, subsequent caries activity experience are often correlated with. Dental caries tooth decay is one of the most prevalent and costly biofilmdependent oral diseases. The role of streptococcus mutans in the formation of dental caries. Organic acids produced by toothdwelling bacteria dissolve the mineralized tissues of the tooth, and the resulting carious lesion progresses inward from the tooth surface.
Feb 03, 2012 role of microorganisms anddental plaque. Caries are caused by a complex interplay of factors, especially patient diet and the presence of the bacteria streptococcus mutans on the teeth. An important virulence property of the bacterium is its ability to form biofilm known as dental plaque on tooth surfaces. Cariescausing biofilms or plaque develop when virulent species, such as streptococcus mutans and other bacteria, utilize dietary sugars to accumulate on tooth surface through eps production, and acidify the local environment. Streptococcus mutans is considered one of the primary causative agents of dental caries and can also be a source of infective endocarditis. Dental caries in very young children may be severe, result in serious infection, and require general anesthesia for treatment. The role of streptococcus mutans in the formation of dental. It is the destruction of dental hard acellular tissue by acidic byproducts from the bacterial fermentation of. Departmentt ofimmnolology andmedical microbiology, college ofmedicinie, anid department ofmicrobiology, university offlorida, gainesville, florida 32601. Dec 01, 2007 the streptococcus mutans is a potent initiator of caries because there is a variety of virulence factors unique to the bacterium that have been isolated that play an important role in caries formation.
Role of streptococcus mutans surface proteins for biofilm. Streptococcus sobrinus in dental plaque samples from brazilian. Not long afterward, stephan and miller 2 provided a compelling demonstration of plaque composition differences between sound and carious enamel sites by measuring changes in. Streptococcus mutans, the most common acid producer in caries, is not always present and occurs as part of a complex. To evaluate at the hard tissue level the effect of c. Dental infections such as tooth decay and periodontal disease are perhaps the most common bacterial infections in humans. Dec 21, 20 to understand the roles of ms in dental caries development, it is important to consider s. The role of bacterial biofilms in dental caries and. Assessment of relationship between streptococcus mutans, dental caries and tgf. Although it is one of the most common ailments on the planet, dental caries, more commonly known as cavities, remains a poorly understood disease. In order to extend the knowledge of the nature of streptococcus infections, an attempt to face the following problems will be made. The effect of cariespreventive measures in mothers on dental caries and the oral presence of the bacteria streptococcus mutans and lactobacilli. Saliva and dental caries new jersey medical school. This bacterium has been reported to be very acidogenic and aciduric in vitro and cariogenic in rats and should, therefore, have at least some cariogenic potential in humans.
An extended ecological plaque hypothesis takahashi and nyvad 2011 incorporates roles. The role of streptococcus mutans and oral ecology in the formation of dental caries. Role of the streptococcus mutans gtf genes in caries induction in the specificpathogenfree rat model. Streptococcus mutans extracellular dna levels depend on the. Gbpb is considered to have some roles in the cariogenicity of s. Detection of streptococcus mutans and streptococcus.
Most commonlylactobacillus, streptococcus mutans, andactinomyces species are associated withdental caries. Many different bacteria are involved in these processes and one among them is streptococcus mutans which is the principle and the most important agent. Dental caries, or tooth decay, is an infectious disease of the dentition characterized by localized destruction of the tooth. Describe two characteristics of streptococcus mutans that contribute to its ability to cause dental cavities. Much is known about the role of streptococcus mutans in the caries process, but the role of s.
Adherence inhibition of streptococcus assay reflecting. In addition, this organism also produces glucosyltransferases, multiple glucanbinding proteins, protein antigen c, and collagenbinding protein, surface proteins that. Assessment of relationship between streptococcus mutans. Kilian clarke 1 first proposed a role for streptococcus mutans in 1924. Mutans streptococci and lactobacilli are strong acid producers and hence cause an acidic environment creating the risk for cavities 14. Tobacco andor nicotine have documented effects on s. The lowph environment in the biofilm matrix erodes the surface of the teeth and begins the initiation of the dental caries. Prevalence and localization of streptococcus mutans in infants and children.
The main virulence factors associated with cariogenicity. Role of streptococcus mutans surface proteins for biofilm formation. Are the mutans streptococci still considered relevant to. Mutans streptococci have been correlated with human dental caries. Y yamashita, w h bowen, r a burne, and h k kuramitsu department of pediatric dentistry, university of texas health science center, san antonio 78284. Role of sortase in streptococcus mutans under the effect of. Role of candida albicans on enamel demineralization and on acidogenic potential of streptococcus mutans in vitro biofilms there is growing evidence that c. Oct 18, 20 streptococcus mutans is a common grampositive bacterium and plays a significant role in dental caries. The complete genome sequence of streptococcus mutans, a bacterial pathogen commonly associated with human dental caries, was published in 2002. The virulence of streptococcus mutans and the ability to form. The distribution of streptococcus mutans and streptococcus. The effect of cariespreventive measures in mothers on dental caries and the oral presence of the bacteria streptococcus mutans and lactobacilli in their children.
Dental caries is a transmissible bacterial disease caused primarily by the bacteria listed above feeding on the carbohydrates taken into the mouths of humans. Role of sweeteners in the etiology and prevention of dental caries shigeyuki hamada department of oral microbiology, osaka university faculty of dentistry, suitaosaka, 5650871, japan abstract. Streptococcus mutans is one of the etiological agents of dental caries, one of the most common human infectious diseases 1,2,3. Streptococcus mutans are anaerobic and are mostly found between adjacent teeth or in the deep crevices on the biting surface of teeth. Caries vaccinationin rats, experimental dental caries have been reduced by immunizing with cell. Dental caries and dental plaque are among the most common diseases worldwide, and are caused by a mixture of microorganisms and food debris. The role of streptococcus mutans in the formation of. The streptococcus mutans is a potent initiator of caries because there is a variety of virulence factors unique to the bacterium that have been isolated that play an important role in caries formation.
The virulence of streptococcus mutans and the ability to. Streptococcus mutans has been implicated as a primary causative agent of dental caries in humans. Cytokine induction by streptococcus mutans and pulpal. Biofilm formation as a complex process of proteinbacterium interaction. Streptococcus mutans is a facultative colonizer of the human dental plaque, the microbial pellicle that covers the surface of the teeth. Chronic pulpal inflammation under caries appears to be elicited by bacterial antigens that diffuse into the pulp through dentinal tubules. Caries causing biofilms or plaque develop when virulent species, such as streptococcus mutans and other bacteria, utilize dietary sugars to accumulate on tooth surface through eps production, and acidify the local environment. Streptococcus mutans is an important species in oral microflora and its components have been found to stimulate production of cytokines in dental caries. Dental caries results from a shift within the biofilm community specific to the tooth surface, and acidogenic species are responsible for caries. Streptococcus mutans is one of cariogenic microorganisms associated with tooth decay. Dental caries is a multifactorial disease that is caused by an interplay of three major factors, i. Specific types of acidproducing bacteria, especially streptococcus mutans, colonize the dental surface and cause damage to the hard tooth structure in the presence of fermentable carbohydrates e. The role of streptococcus mutans and oral ecology in the.
Yet, perhaps the most beneficial feature of the saliva in the mouth is its ability to promote the adhesion of microbial species by coating surfaces of the oral cavity with a selective conditioning film. The best example of biofilm formation is dental plaque. The tooth surface is covered with a biofilma slime layer. The bacteria that are trapped in the capsule use the other sugar to fuel their metabolism and produce in nutritional disease. Within that framework there are considerable differences of opinion regarding the importance and relative contributions of the mutans. Role of candida albicans on enamel demineralization and on.
Structural and molecular basis of the role of starch and. The role of fructans on dental biofilm formation by streptococcus sobrinus, streptococcus mutans, streptococcus gordonii and actinomyces viscosus ramona rozen department of oral biology, faculty of dentistry, hebrew universityhadassah, p. Nutrients free fulltext streptococcus mutans, caries. Streptococcus mutans is a common grampositive bacterium and plays a significant role in dental caries. Role of sortase in streptococcus mutans under the effect. Request pdf on researchgate the role of streptococcus mutans in human caries definite proof has been found that s.
It is the destruction of dental hard acellular tissue by acidic byproducts from the bacterial fermentation of dietary carbohydrates especially sucrose. Role of the streptococcus mutans gtf genes in caries. Streptococcus sobrinus and streptococcus mutans in a. Streptococcus mutans, which causes dental caries, splits the sucrose in food and uses one of the sugars to build its capsule, which sticks tightly to the tooth. The importance of streptococcus mutans in the etiology and pathogenesis of dental caries is certainly controversial, in part because excessive attention is paid to the numbers of s. Major putative caries pathogens include the mutans streptococci, streptococcus mutans and streptococcus sobrinus, and various lactobacillus species.
Samia elazab 15102016 c microorganisms the most potent acid producing strains is streptococcus viridians st. Plaque formation can lead to dental caries and other associated diseases causing tooth loss. Streptococcus mutans extracellular dna levels depend on. Caries vaccinationthe following mechanism have been suggested. Some of the first studies addressing this issue compared the ability of clinical isolates of s. The relationship between the bacterium streptococcus mutans in the saliva and dental caries in children in mozambique. Nanocatalysts promote streptococcus mutans biofilm matrix. If this is so, then dental caries and periodontal disease can be consideredas specific, treatable infections. Growth is not inhibited by low ph that is produced by lactic acid that the bacteria produce during fermentation. He will be attending umdnj dental school in fall 2012. Role of sweeteners in the etiology and prevention of.
Bacteriological studies have helped toclarify the role of microorganisms in theetiology of dental caries. Jun 16, 2017 streptococcus mutans and dental caries oral pathology. Role of intracellular polysaccharide in persistence of. To understand the roles of ms in dental caries development, it is important to consider s. Ms diversity was later shown to influence the ability of individual ms strains to be. Get a printable copy pdf file of the complete article 6.
91 797 639 1085 1123 632 961 825 1127 1470 344 333 182 510 1014 817 565 958 876 535 128 877 392 211 506 591 515 979 110 624 254 580 969 332 1299 880